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In mice with acute lymphocytic choriomeningitis virus, CD4+ T cells with the silence of mechanistic target of rapamycin complex-2 (mTORC2) impede the formation and growth of memory CD4+ T cells, which is attributed to the IL-7-activated mTORC2AKTGSK3 signaling pathway, leading to excessive GPX4 peroxidase and suppression of ferroptosis in memory cells (98)

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Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial