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They may be promising in animal models, early human work, or small specialty settings, but they are not broadly approved therapies

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This is an autoimmune disorder caused by a lack of red blood cells when the body is not able to absorb enough vitamin B12

Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design