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Established that NAMPT-mediated NAD+ biosynthesis is regulated by CLOCK/BMAL1 circadian transcription factors, creating a circadian oscillation of NAD+ that drives SIRT1, SIRT3, and SIRT6 activity

Mecobalamin also contributes to the normal production of red blood cells and participates in DNA synthesis, making it an important nutrient for healthy cell division and tissue maintenance

Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)