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Covalent linkage of DOX to three different types of NPs-metallic, silica/organo-silica and polymeric has been shown to overcome its cardiotoxicity (77)

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Renal impairment was defined as mild with eGFR values of 6089 mL/min, moderate eGFR 5930 mL/min and severe with eGFR values 56 mol/l, can lead to encephalopathy and status epilepticus [34, 35], whilst in most people ASM-induced HA is of minor clinical significance