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While certain environmental factors, like using dietary fiber, whole grains, dairy products, and dietary supplements like vitamin D3 [177] and calcium [179], are associated with a lower risk of colon cancer and may have beneficial effects [177, 179, 181], others, such as a sedentary lifestyle and obesity [177, 181, 182], smoking, alcohol consumption [177, 181], and the consumption of red and processed meats [177, 182], are related to a risen risk and can contribute to the progression of the disease

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