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The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis

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Renal health A meta-analysis to estimate the overall hazard ratios for kidney and key safety outcomes (severe hypoglycemia, pancreatitis, and pancreatic cancer) showed that GLP-1 RAs reduced the overall composite kidney outcomes (new-onset macroalbuminuria progression, estimated glomerular filtration rate decline [or increase in creatinine], end-stage kidney disease progression, or death due to kidney causes) by 17% mainly due to a reduction in urinary albumin excretion [60]