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When GLP-1 binds to these receptors, it can shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, inhibit the production of pro-inflammatory cytokines like TNF-, IL-1, and IL-6, increase anti-inflammatory adiponectin, and inhibit NF-B, a key regulator of pro-inflammatory gene expression

The p62-Keap1-NRF2 pathway plays an important role in preventing ferroptosis in HCC cells, and the RAS/Raf/MEK pathway is an important target for the treatment of HCC 32,40

Creatine Monohydrate: normally creatine is loaded into muscle with a 5g dose with foods, or a small carbohydrate snack