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Outside narrow, documented medical need, compounded versions of these drugs are no longer a lawful option, and FDA has logged hundreds of adverse event reports, some requiring hospitalization, tied to dosing errors from patients measuring their own doses out of compounded vials

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The Rybelsus pill also requires significantly more active ingredient than shots, and that substance, semaglutide, is already in short supply

However, 69 T2DM patients receiving metformin were also given either exenatide ( n = 36) or insulin glargine ( n = 33)