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While dietary interventions emphasizing protein, fiber, and whole foods can improve metabolic parameters and support weight management, the effects are generally more modesttypically 3-5% weight loss and HbA1c reductions of 0.5-1.0% when implemented without other interventions, as seen in programs like the Diabetes Prevention Program

doi: 10.1002/biof.1797 51 BruinstroopEZhouJTripathiMYauWWBoelenASinghBKet al

used ultra-high-performance liquid chromatography to determine the content of paeoniflorin in Paeonia lactiflora Pall (Ren et al., 2015)

As you lose weight on tirzepatide , your levothyroxine dose may need reduction, so monitor thyroid function regularly during significant weight loss