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For example, excessive alcohol consumption promotes the translocation of intestinal -glucan to the liver, where it binds to Dectin-1 on liver macrophages, activating the NLRP3 inflammasome and contributing to the development of alcoholic hepatitis (Wu et al., 2020b)

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To test this, we inhibited the cysteine/glutamate antiporter System Xc - using Imidazole Ketone Erastin (IKE), thereby limiting substrate availability for GSH synthesis ( Figure 6H )

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