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In NAFLD/MASLD, antioxidant approaches (vitamin E, glutathione) show modest biochemical and histological benefit mainly in earlier, non-cirrhotic stages, but robust outcome data in advanced disease are lacking (Sumida and Yoneda, 2018)

NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier

So while this comparison raised questions about how the treatment stacks up against competitors, it doesnt necessarily affect its chances of approval