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Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

BMC Genom 11:648

202 while SIRT1 inhibition in HSCs may prove beneficial during fibrosis

Protein oxidation causes odd protein structure and function, involving enzyme inactivation and distublance of cell signal transduction, straightly influencing the activity of fibroblasts and osteoblasts (Sharifi-Rad et al., 2020), ( Moreover, DNA damage activates stress response mechanisms within cells, possibly causing apoptosis or mutation, further compromising the health of gingival tissues ( 2.3.3 Depletion of antioxidant systems During the prolonged progression of chronic periodontitis, oxidative stress persists, causing depletion and imbalance of antioxidant systems (Shang et al., 2023)