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Description

Both malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) are reactive aldehydelipid peroxidation by-products (see Figure 2) that have been widely used as biomarkers of OxS [59,60]

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Additionally, O 2 can react with nitric oxide (NO) to generate excessive ONOO, activating caspases, causing lipid peroxidation, and leading to either apoptosis or necrosis [49]

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