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This study was conducted in Japan, South Korea, Taiwan and the Philippines, where patients with type 2 diabetes have a number of distinct features, including a relatively low body mass index (BMI) (in this study a mean of 25.3 kg/m 2 ) and tend to have reduced cell function compared with Western subjects

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It adds that heterogeneity in berberine dosing and formulation quality complicates comparison across trials, while GLP-1 data covers glycemic control, weight, cardiovascular mortality, and kidney outcomes

Furthermore, no adverse reactions or toxicity were observed during the treatment (555)