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5.3 Inhibition of free fatty acid key target TLRs FAs promote the development of GA and trigger the initiation of inflammation, mainly by activating its downstream key targets TLR2/TLR4 (172, 173)

The European Commissions report on public health from 2023 highlights the investment of millions in improving diabetes care, which promotes the uptake of insulin and GLP-1 receptor agonists

Apart from the standard pharmacovigilance and RMP update requirements, the TGA uses an enhanced post-market monitoring and compliance framework, and prioritises provisionally approved medicines for post-market surveillance activities

Blood pressure actually improved in most participants, a benefit attributed to weight loss and improved insulin sensitivity outweighing any direct cardiovascular stimulation from the drug itself