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Characterized by their unpaired electron(s), superoxide radicals, hydroxyl radicals, hydrogen peroxide, nitric oxide, lipid alkoxyl and peroxyl radicals are the most common reactive oxygen species in living, aerobic systems[2]

Resveratrol alleviates cardiac apoptosis following exposure to fenitrothion by modulating the sirtuin1/c-Jun N-terminal kinases/p53 pathway through pro-oxidant and inflammatory response improvements: In vivo and in silico studies

When 25 M quercetin was administered after infrared radiation treatment (5 Gy), p21 CIP1 and p16 INK4 expression levels were significantly reduced compared with infrared radiation treatment alone, and cell viability of SAOS400 (an osteosarcoma cell line obtained after simulated clinical sublethal dose of -ray irradiation) was significantly reduced by about 29% 21 ( Figure 1 and Table 1)

We found that cancer cells with -KG insufficiency exhibit cytosolic NADPH depletion because of defective FAO and TCA cycle, highlighting the importance of -KG in regulating NADPH homeostasis through mitochondrial metabolism