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For more pronounced changes, such as significant skin brightening and the fading of hyperpigmentation, consistent treatment over three to six months is often required

9 The presence of oxidized GSTP1-1 has recently been discovered in human saliva, 11 but it has never been observed in mammalian blood

If you are concerned about a loss of collagen, more visible dark spots and other forms of intense hyperpigmentation, a 10% Vitamin C serum or higher applied twice daily may be ideal for you

The same goes for individuals with acute infections or conditions affecting their liver, or those with open wounds or skin infections in the area of application