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This review delineates the molecular and cellular pathways by which Hg exerts neurotoxic effects, emphasizing its disruption of the glutamateglutamineGABA cycle and the resulting excitotoxic activation of NMDA receptors

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78 These changes stabilize its structure, prevent protein degradation of the molecule in the circulation, and increase the circulation time enough to ensure once-daily injection (compared with exenatide, which is injected two or three times daily)