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J Prev Alzheimers Dis 12:100022

Downregulated expression of occludin and zonula occludens-1 is related to increased matrix metalloproteinases levels in diabetes in both rats and humans [37,38], and inhibition of matrix metalloproteinase-9 prevents increased leakage in streptozotocin-induced diabetic mice [39]

Researchers tried accounting for other factors that could have affected their cognitive function, like age, education, and drug and alcohol use, but the results still held

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