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DUAL AGONISTS OR COMBINATIONS Semaglutide is the post powerful of the GLP-1RAs currently available, but very powerful combinations of GLP-1RAs with other weight-regulating hormones and also monomolecular agonists with dual or triple action on the receptors for these hormones are now being introduced

In some embodiments, the otic formulation or composition comprises between about 0.1% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Tirzepatide, a dual GIP and GLP-1 receptor agonist approved by the FDA, has demonstrated cardiovascular safety in large clinical trials without evidence of pathological cardiac atrophy