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Sermorelin effects typically appear over weeks as growth hormone levels gradually rise, while tirzepatide side effects can emerge within days of the first dose as your gut receptors adjust to signaling changes

Slower-than-expected weight loss on tirzepatide doesn't necessarily indicate treatment failureit may reflect individual differences in GLP-1 and GIP receptor sensitivity, baseline metabolic health, lifestyle factors, and medication timing

Note whether this happens after meals, at night, or throughout the day

nonetheless, this weakness can later develop to distal weakness of foot and toe dorsiflexion, which puts patients at risk for falling