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Over the course of 2128 days, SAR425899 evidences maximal BW reduction of 5.32 kg in healthy/overweight patients, while overweight/obese patients with T2D experienced maximal BW reductions of 5.46 kg along with significant reductions in fasting plasma glucose and glycated hemoglobin [177]

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In addition, melanotan 2 seems to work synergistically with naltrexone (boosting efficacy by over sevenfold) to reduce binge-like ethanol intake in subjects (5)