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This etiological link is further supported by the finding of higher melanoma incidence in populations that live in lower latitudes, higher incidences in white populations, lower incidences among darkskinned populations, and data from genetic and migration studies [3234].

Its essence is that metal ions and ligands (such as amino acid residues in proteins) form a thermodynamically stable metal-ligand complex through the synergistic action of covalent bonds and coordination bonds

Possible side effects include[10]: Bloating or abdominal discomfort Nausea or vomiting Diarrhea Headaches Dizziness or feeling lightheaded Flushing or low blood pressure Rare but serious reactions, such as allergic responses or irregular heartbeat, have been reported, especially in individuals with heart conditions