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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

The authors attributed this effect to the lipophilicity of the esterified derivatives of GSH

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