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Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity

This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins

Liver Enlargement and Hepatotoxicity Both enzyme induction and proliferation of endoplasmic reticulum are responses that enhance metabolism and detoxification

This disrupts the antioxidant balance, harms photosynthesis, and affects cellular homeostasis (Fig