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In vitro, we found that in PSCs, high ROS accumulation attributed to high glucose was associated with PSC activation, which was characterized by increased expression of -SMA, accelerated migration, and increased synthesis of ECM proteins such as collagen I, all of which were rescued by GSH treatment

Additionally, activating the SIRT1/Nrf2/p62 pathway can promote the healing of diabetic foot ulcers, possibly mediated by autophagy-dependent ferroptosis ( Together, the diverse roles of SIRT1 across multiple disease types underscore its significance as a promising therapeutic target

Step 5: The Reconstitution Swirl Once all the BAC water is in the vial, carefully remove the syringe