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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

protect from moisture and light exposure Avoid room temperature storage for extended periods Use aseptic technique with reconstituted solutions Inspect visually before use

Protein drinks are a particularly key area: GLP-1 drugs can cause rapid weight loss, including the loss of muscle tissue (studies show that nearly 40% of weight loss on GLP-1s can be lean mass without proper nutritional support)

Hematocrit should be checked at 36 months then annually, with testosterone dose reduction if levels exceed 54%, while testosterone levels should be monitored at 36 months after initiation or dose changes