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Another important issue that arises from (alleged) scientific fraud is that it creates a culture of research that pushes towards an extremely unlikely hypothesis, in the misbelief that the hypothesis is likely given the nature of the publications (also see Fanelli, Costas & Ioannidis, 2017)

Nerve damage is thought to affect up to half of people with diabetes

For coronary artery disease, where partial blockages reduce blood flow to heart muscle, enhanced collateral development could improve myocardial perfusion