The MHRA has approved specific GLP-1 receptor agonists for weight management (Wegovy and Saxenda) in individuals with a body mass index (BMI) of 30 kg/m or above, or 27 kg/m with weight-related comorbidities, while others are approved only for glycaemic control in type 2 diabetes
The maintenance doses used in these trials include: 4 mg once weekly 9 mg once weekly 12 mg once weekly For those taking the maximum 12 mg dose , they follow a gradual increase that looks like this: 2 mg 4 mg 6 mg 9 mg 12 mg (highest dose studied) Each increase happens every 4 weeks , similar to the phase 2 studies, so the full build-up takes about 16 weeks before staying at 12 mg for the rest of the study
For example, phentermine can cause a rapid or irregular heart rate, high blood pressure, headache, and insomnia
Back Habert, R (May 2022) 'Claude Bernard, the Founder of Modern Medicine', Cells , 11/10, 1702