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Lipid peroxidation, created by free radicals attacking cell membranes, results in the production of lipid peroxidation derivatives, including 4-HNE, MDA, and many other toxic aldehydes.[] HNE can damage beta cells of the pancreas and impair the ability of muscle and the liver cells to respond to insulin

To find out a specific mechanism, a comparison with the becaplermin (recombinant human plateletderived growth factor homodimer of B chains, PDGF-BB) was the focus of the two additional studies using excisional wounds in diabetic rats and mice (Figure 2) (Seveljevic-Jaran et al., 2006

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It increases coronary blood flow and reduces vascular resistance, contributing to improved cardiac function and protection against ischemic injury [41]