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Assessment of consistency across finngen, PGC, UKB, and other GWAS datasets with meta-analysis To evaluate the consistency of our findings across multiple independent datasets, we conducted Mendelian randomization (MR) analyses using summary genetic data from the FinnGen consortium (R9) ( Psychiatric Genomics Consortium (PGC, and UK Biobank ( The number of individuals included in these analyses ranged from 133,164 to 306,119, as detailed in Supplementary Table S2

For weight management, you may be suitable for semaglutide, tirzepatide or other GLP-1-based treatment if you have a BMI of 30 kg/m or higher, or a BMI of 27 kg/m with a weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes