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Summary of completed and ongoing clinical trials of GLP-1RAs for neurodegeneration In summary, clinical trials investigating GLP-1RAs in neurodegenerative diseases have yielded contrasting outcomes

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From the 4 mg dose, reaching nearly 20% weight loss with one escalation step, to the 12 mg dose that delivered a level of weight loss long associated with bariatric surgery, retatrutide offers the potential for a patient-centric approach to obesity

GLP-1 is released in response to food intake, and has several important functions, including stimulating insulin release, suppressing glucagon release, slowing gastric emptying, and reducing appetite