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Meanwhile, NF1 is significantly co-mutated with KIT in 32% of MMs, whereas the co-occurrence level in CM is merely 4% (99), which indicates that the MAPK cascade is upregulated in MM not only by the single protein in the cytoplasm but also by the assistance of C-KIT receptor on the cell membrane

Using the SIRF assay, we observed a significant reduction in RAD51 (Supplementary Fig