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These systems don't operate in isolation

In particular, in vitro eryptosis was induced in RBCs from healthy volunteers after exposure to plasma from septic patients [126]

Notably, HIF-2, another key HIF family member also regulated by hypoxia and sharing some target genes, may exhibit distinct roles from HIF-1 in ROS regulation, sometimes even promoting ROS generation under specific conditions, highlighting the nuanced complexity of this family in ROS homeostasis [136]

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