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Supporting this model, transcriptomic analysis of 3xTg-AD mice at different disease stages (2, 10, and 20 months) revealed age-related increases in DAM-associated genes such as Trem2, Tyrobp, Clec7a , and Cd68 , particularly in aged AD mice compared to young AD mice and aged-wild-type controls (Lambracht-Washington et al., 2023)

In recent years, research on the application of glycyrrhizin in DILI has remained a focus of active research

The signal in breast cancer patients pointing to C2 as the lone AC suggests the malignant tissue invokes the metabolic flexibility pathway as it switches between glucose and fat utilization