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The reduced glutathione (GSH), as a key antioxidant, is synthesized exclusively in the cytosol through two ATP-dependent enzymes, namely -glutamyl-cysteine ligase (GCL), which is comprised of two independent subunits GCLC and GCLM

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Peptides with fewer residues are more susceptible to rapid enzymatic degradation, leading to shorter systemic exposure. Fosgerau & Hoffmann, Drug Discovery Today Half-Life Each peptide has a defined biological half-life the time it takes for half of the substance to be eliminated from the bloodstream