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That is why it often gets mentioned for overuse injuries

J Clin Invest 86 : 265272 Mauras N and Haymond MW (2005) Are the metabolic effects of GH and IGF-I separable

For women of reproductive age with PCOS, the priority is to simultaneously strengthen fertility planning and contraceptive management while improving ovulatory opportunities, ensuring weight and metabolic stability during the preconception washout period to avoid the maternal-fetal risks associated with a weight lossrebound cycle (133, 137)

Lee, J.Y