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The metabolic syndrome is the soil out of which diabetes, heart disease, and all of these other chronic diseases grow and its characterized at its core by insulin resistance and hyperinsulinemia

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Many insurance plans require documented diet and exercise attempts, require prior authorization, or limit coverage to patients with specific comorbidities

However, this strategy is only attractive if the therapeutic agent itself is not a substrate for CPA, or if the case, that its functional activity is not negatively affected by C-terminal cleavage