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On GD 7.5, Ferrostatin-1 (Fer-1, GC10380-25mg, GLPBIO, USA) and Quercetin (QCT, GN10266-5g, GLPBIO, USA) were intraperitoneally injected at 2 mol/kg/day and 2 mg/kg/day, respectively, while Sham and sRUPP groups received equivalent saline injections

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Common effects of sudden discontinuation include: Return of appetite : The appetite-suppressing effects diminish, often leading to increased hunger and food cravings Blood glucose elevation : For those with type 2 diabetes, blood sugar levels typically rise as the glucose-lowering effects wear off Weight regain : Many patients experience weight increase, sometimes rapidly, as metabolic changes reverse Gastrointestinal changes : The slowed digestion that Ozempic provided normalises, which some patients notice as altered bowel habits It is important to understand that stopping Ozempic suddenly does not typically cause dangerous withdrawal symptoms in the traditional sense

doi: 10.1038/nrc3106