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(117) proposed that the degeneration of spinal components is associated with gut microbiota anomalies and separately categorized osteoporosis, synovial osteoarthritis, disc degeneration, spinal sarcopenia, and lumbar stenosis under spinal degenerative diseases (SDD), introducing the concept of the gutspine axis for the first time

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As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively