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Semaglutide also showed largely positive effects with four studies reporting reduced A or tau pathology, though one study reported no benefit

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Gut microbiota is also involved in signaling of FXR and TGR5 by modifying the bile acid pool (182)

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doi: 10.1113/jphysiol.1985.sp015794

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APOE and Alzheimer disease: a major gene with semi-dominant inheritance

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