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Alzheimer's Hallmarks: A and Phosphorylated Tau The neuropathology of AD is characterized by an abnormal build-up of extracellular amyloid- (A) peptide as neuritic plaques, pathological extracellular aggregates formed around a core of A and are a hallmark of AD (Stratmann et al., 2016), accompanied by intracellular hyperphosphorylated (p)-Tau fibrils which accumulate as neurofibrillary tangles (NFTs) within neurons (Stratmann et al., 2016)

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To strengthen the bodys defence against oxidative stress, selenium aids in activating these antioxidant enzymes (137)

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