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Because of epitalons action on melatonin production, nighttime administration is ideal

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Ethics statement: Written informed consent was obtained from all subjects prior to participation, and the protocol was approved by the ethics committee in the Faculty of Pharmaceutical Sciences, Toho University (approval number 23-1, 24-6)

The active site of the enzyme that binds glycine to the dipeptide -L-glutamyl-L-cysteine is highly specific (57)