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Stop immediately if severe symptoms occur, such as breathing difficulty, sudden chest pain, severe rash, jaundice, or syncope, and seek emergency care

GLP-1-related signals may be integrated through the brainstemhypothalamic axis with interoceptive input arising from gastrointestinal and metabolic states, thereby modulating the homeostatic drive to eat (89)

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However, as DPP4 recognizes other substrates such as chemokines, growth factors and neuropeptides, pleiotropic effects have been observed in patients treated with DPP4i