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Due to the exhaustion of cellular and extracellular GSH caused by numerous GSH-consuming pathways the severe inflammation and oxidative stress triggered by the viral infection steals GSH from crucial functions like NO-dependent vasodilatation, disallowing the patient of being protected from an inflammation that can become fatal

doi: 10.1002/oby.24177

Freezing causes ice crystal formation that physically disrupts peptide structure and precipitates the lipotropic compounds out of solution

Discussion Compared to individual parameters, composite biomarkers may provide a more robust method for evaluating disease progression in response to a study intervention than a single efficacy outcome [28]