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Lee PHA, Ohtake T, Zaiou M, Murakami M, Rudisill JA, Lin KH, Gallo RL: Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection

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By combining rational peptide design, strategic amino-acid substitutions and albumin-binding acylation, with systematic, hypothesis-driven experimentation, investigators achieved a pharmacokinetic profile (approximately 160 h half-life) that made OW dosing clinically feasible without compromising receptor potency or safety