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Hypoglycaemia : Risk increases when combined with sulphonylureas or insulin, necessitating dose adjustments of these agents

Associate Professor Clare Arnott, Director of Global Chronic and Complex Diseases and Cardiovascular Programs at the Sydney office of The George Institute for Global Health, said the trial was extremely exciting as it was the first large semaglutide study in a dedicated HFpEF population

Rare but serious risks include pancreatitis, gallbladder disease, and a thyroid C-cell tumor risk based on rodent studies (semaglutide carries a boxed warning and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2)

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