Additionally, targeted delivery systems, such as intra-tympanic or nanoparticle-based approaches, could direct the drug specifically to the cochlea or central auditory structures, increasing local efficacy while reducing exposure to other brain regions and peripheral organs
A recent study conducted on mice models of PD established that the N-homocysteinylation of -SN enhances its aggregation potential and increases its neurotoxicity and that higher Hcy levels correlated with more severe -synuclein deposition within mouse brains (Zhou et al
Mader E K, Maeyama Y, Lin Y, et al
Examples of the overall distribution of GPX1-positive cells in selected islets from several donors are depicted as assembled micrographs, where the first column shows the presence of GPX1 cells alone within islets and the surrounding regions, the second column displays merged images of cells positive for GPX1 (brown GPX1 cells converted to a blue pseudo colour), insulin (green) and glucagon (red), while the third column shows corresponding fields after counterstaining with haematoxylin (Figs
