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4) (Gouda et al., 2021)

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First-line NHS approaches typically include: Structured dietary advice and calorie reduction Increased physical activity tailored to the individual Behavioural support through NHS weight management programmes or Tier 2/3 services Pharmacological treatment may be considered when lifestyle interventions alone are insufficient

S100A15 directly acts as a chemoattractant, promoting the infiltration of inflammatory cells and amplifying the pro-inflammatory cascade in the skin