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The concentration of leukotriene D(4) (LTD(4)), which is usually not detectable, was highly increased, whereas LTE(4), the major urinary metabolite in humans, was completely absent

In infant populations, bottle-fed babies exhibit reduced fecal microbiota diversity and decreased numbers of beneficial bacteria such as Bifidobacterium and Parabacteroides [77]

It is possible for different types of hypersensitization and provocation to be effective in the same organ but it is also possible for the route of sensitization and response to subsequent challenge to differ, e.g., sensitization via the skin and subsequent asthma on inhalation exposure

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